Ondansetron Hydrochloride Injection IP – Efest

Ondansetron Hydrochloride Injection IP – A one-stop solution for emesis.

Efest – Ondansetron 2mg/ml

Ondansetron Hydrochloride Injection IP is an antiemetic medication used to manage nausea and vomiting. It works by acting both centrally and peripherally by blocking 5-HT3 Receptors in area postrema in the brain and depressing the chemoreceptor trigger zone (CTZ) that helps in medicating the sensation of nausea and vomiting and peripherally as it antagonizes 5-HT3 Receptors that can be found on vagus nerve terminals which transfer signals to the brain and transmit a sensation of nausea and vomiting. Thus, it prevents the management of nausea sensation by action both centrally and peripherally through the antagonism of the 5-HT3 receptor.

Recommended by which specialists:
✅Gastroenterologists: For managing nausea/vomiting due to acute gastroenteritis, gastritis, or gastroparesis
✅General Physicians: For acute nausea and vomiting in emergency or outpatient settings

Key benefits of Ondansetron Hydrochloride Injection IP – Efest
✅First-line therapy for the management of Chemotherapy and radiation therapy induces nausea.
✅FDA-approved for the prevention and treatment of nausea induced by Chemotherapy, radiation therapy, and post-operative nausea.
✅Dual Mechanism of Action: It acts centrally (depressing CTZ) and peripherally (on vagus nerves in the GI tract) to prevent and manage nausea and vomiting.
✅Flexible Dosage Forms: Availability in multiple dosage forms, such as dispersible tablets, drops, and injections, enhances dose flexibility and improves patient compliance.

Indications
✅Nausea and vomiting in gastroenteritis
✅Chemotherapy induces nausea & vomiting
✅Radiation therapy-induced nausea & vomiting
✅Post-operative nausea & vomiting